What is gout arthritis? How does uric acid cause inflammation?



How to Treat Hyperuricemia

Two Methods:

Hyperuricemia is an excess level of uric acid in the blood, and is one of the primary causes of gout. The treatment of hyperuricemia focuses on controlling the high level of uric acid in the body and the symptoms associated with it. If you are suffering from hyperuricemia, you can seek professional medical treatment, or try home remedies.

Steps

Using Medical Treatment

  1. Try NSAIDs to relieve pain and inflammation.This medicine works by blocking specific body chemicals that cause inflammation.
    • This helps to reduce pain in the joints by inhibiting the production of COX in the brain.
    • In turn, this reduces the intensity of your pain.
    • Take acetaminophen (Tylenol), at a dosage of two tablets three times daily.
    • The maximum dose of Tylenol is 4000mg daily and this should not be exceeded because it can damage your liver.
    • You can also try naproxen sodium and ibuprofen.
    • NSAIDs are usually prescribed for about 7 to 10 days, or until inflammation has been relieved.
    • If you have increased acidity in your body, you should avoid taking NSAIDs.
  2. Take uricosuric drugs to block the reabsorption of uric acid.Uricosuric drugs block the reabsorption of urate, thus preventing formation of uric acid crystals in the tissues and increasing the excretion of uric acid from the body.
    • This drug type includes Probenecid and Sulfinpyrazone.
    • The starting dose for Probenecid is 250 mg two times a day, and can be increased to a maximum dosage of 3 grams daily.
  3. Get an intravenous saline solution to decrease the concentration of uric acid in your body.In severe cases, you can receive intravenous fluid that contains saline to help decrease uric acid in your body.
    • This can be given as a continuous infusion of 2L per 24 hours.
  4. Take furosemide to dilute your urine.You can take furosemide (lasix) to dilute your urine.
    • This drug acts by increasing the elimination of uric acid through your urine.
    • The usual dose is 20 mg once a day but this may be adjusted depending on your condition.
  5. Try xanthine oxidase inhibitors to decrease uric acid production.Xanthine oxidase inhibitors decrease your uric acid production by inhibiting the production of xanthine oxidase, an enzyme responsible for the production of purine.
    • This class of drugs includes Allopurinol.
    • A maintenance dose for adults is 200 to 300 mg per day.
    • The use of Allopurinol can result in fatal hypersensitivity, so take it only under the direct supervision of a medical professional.
  6. Take carbonic anhydrase inhibitors.Carbonic anhydrase inhibitors decrease the solubility of uric acid, which allows the body to eliminate uric acid more efficiently.
    • While taking this type of drug, you must maintain adequate hydration in order to sustain high urine output.
    • The dosage of this medication varies, and it is best to consult with your physician for an appropriate prescription.

Using Lifestyle Changes

  1. Avoid purine-rich foods to reduce the concentration of uric acid in your body.Since uric acid is produced from the metabolism of purine in the body, it is best to avoid foods that contain purine.
    • Purine-rich foods are mackerel, anchovies, organ meats, dried beans, peas, canned goods, instant noodles, wine, and beer.
  2. Stay away from foods rich in fructose to reduce your ATP consumption.Foods rich in fructose consume a lot of adenosine triphosphate, or ATP, when metabolized.
    • This ATP is an energy-supplying molecule that the cells in your body use.
    • Large consumption of ATP leads to its depletion, and results in the generation of substances such as lactic acid and uric acid.
    • Foods to avoid are apples, bananas, grapes, pears, agave, melons, asparagus, beans, broccoli, cabbage, onion, tomato, peanuts, raisins, figs, carbonated drinks, fruit drinks, ketchup, canned goods, chocolate, pastries, and breakfast cereals.
  3. Maintain adequate hydration to dilute the uric acid in your body.Increasing your daily intake of fluid helps dilute your urine, decreasing your body's acid level and eliminating toxins from your body.
    • Increasing your intake of water increases your urine output.
    • The more urine output is increased, the more uric acid will be flushed out of your body through urination.
    • Drink at least 10 or more glasses of water daily.
  4. Avoid drinking alcohol to facilitate uric acid removal.Alcohol interferes with the removal of uric acid from the body in a variety of ways, such as:
    • When alcohol is converted to lactic acid, it minimizes the amount of uric acid that is eliminated from the body through the kidneys. This is because the lactic acid competes with the uric acid for removal from the kidneys into the urine.
    • Alcohol increases your body's levels of ethanol (alcohol), increasing your body's production of uric acid.
  5. Eat high-fiber foods to aid uric acid absorption.Dietary fiber may aid your body's absorption of uric acid in your bloodstream, allowing it to be removed by your kidneys.
    • Include at least one high-fiber food in each major meal or snack.
    • Some good high-fiber foods are pineapple, oats, isabgol, cucumbers, oranges, barley, carrots, and celery.
  6. Eat foods rich in anthocyanins.Anthocyanins prevents crystallization of the uric acid and uric acid deposit in your joints.
    • Foods rich in anthocyanins are eggplant, blueberries, cranberries, plums, black currant, grapes, pomegranates, red fleshed peaches, and cherries.
    • You can include at least one of these foods in each major meal or snack.

Community Q&A

Search
  • Question
    What is the role of grams and pulses in hyperuricemia?
    wikiHow Contributor
    Community Answer
    You need to drink a base substance to cancel out the acid. I would recommend eating baking soda, but vinegar works too.
    Thanks!
  • Question
    What foods are high in uric acid?
    wikiHow Contributor
    Community Answer
    Organ meats, like live or kidneys. Meats, like bacon, pork, beef, and lamb. Game meats. Anchovies, sardines, and scallops. Gravy. Beer. Tomatoes, legumes, beans, etc.
    Thanks!
  • Question
    What about drinking liquor like whiskey?
    Hussein Najm
    Community Answer
    Alcoholic drinks should be restricted as a part of lifestyle changes for effective management.
    Thanks!
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Sources and Citations

  1. *Qazi, Y. (2012, November 16). Hyperuricemia. In emedicine.medscape.com. Retrieved from
  2. *Qazi, Y. (2012, November 16). Hyperuricemia. In emedicine.medscape.com. Retrieved from
  3. *Chemocare.com (n.d.). Hyperuricemia (High Uric Acid). Retrieved from
  4. *Qazi, Y. (2012, November 16). Hyperuricemia. In emedicine.medscape.com. Retrieved from
  5. *Chemocare.com (n.d.). Hyperuricemia (High Uric Acid). Retrieved from
  6. *Qazi, Y. (2012, November 16). Hyperuricemia. In emedicine.medscape.com. Retrieved from
  7. *Chemocare.com (n.d.). Hyperuricemia (High Uric Acid). Retrieved from
  8. *Qazi, Y. (2012, November 16). Hyperuricemia. In emedicine.medscape.com. Retrieved from
  9. *Chemocare.com (n.d.). Hyperuricemia (High Uric Acid). Retrieved from
  10. *Qazi, Y. (2012, November 16). Hyperuricemia. In emedicine.medscape.com. Retrieved from
  11. *Qazi, Y. (2012, November 16). Hyperuricemia. In emedicine.medscape.com. Retrieved from
  12. *Chemocare.com (n.d.). Hyperuricemia (High Uric Acid). Retrieved from
  13. *Qazi, Y. (2012, November 16). Hyperuricemia. In emedicine.medscape.com. Retrieved from
  14. *Qazi, Y. (2012, November 16). Hyperuricemia. In emedicine.medscape.com. Retrieved from
  15. *Qazi, Y. (2012, November 16). Hyperuricemia. In emedicine.medscape.com. Retrieved from
  16. *Qazi, Y. (2012, November 16). Hyperuricemia. In emedicine.medscape.com. Retrieved from
  17. *Chemocare.com (n.d.). Hyperuricemia (High Uric Acid). Retrieved from
  • Newcombe, D. S., & Robinson, D. R. (2013). Gout: Basic science and clinical practice. London: Springer London.
  • Weisman, M. H. (2010). Targeted treatment of the rheumatic diseases. Philadelphia: Saunders Elsevier.
  • Terkeltaub, R., & Edwards, N. L. (2011). Gout: Diagnosis and management of gouty arthritis and hyperuricemia. West Islip, N.Y: Professional Communications.
  • Moghul, S. (2013, June 23). 20 foods to keep your uric acid at normal levels. In timesofindia.indiatimes.com. Retrieved from
  • Nakayama A1, Matsuo H, et al (2011, December 30). ABCG2 is a high-capacity urate transporter and its genetic impairment increases serum uric acid levels in humans. In ncbi.nlm.nih.gov. Retrieved from
  • Harris ED, Budd RC, Firestein GS, Genovese MC, Sergeant JS, et al. (2005) Kelly’s Textbook of Rheumatology 7th edn.





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Date: 04.12.2018, 21:38 / Views: 31333